Blood Brain Barrier Query Results
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Study identifies pathway responsible for blood-brain barrier impairment in Alzheimer’s
Click here to view original web page at www.drugtargetreview.com The team found that the expression of the APOE4 gene variant in pericytes caused amyloid plaque formation in a blood-brain barrier model. Development of a model of the human blood-brain barrier (BBB) has enabled researchers to discover how APOE4 gene expression causes amyloid plaques to disrupt … Continue reading “Study identifies pathway responsible for blood-brain barrier impairment in Alzheimer’s”
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Blood-Brain Barrier-in-a-Dish Leads to Alzheimer’s Discovery
Click here to view original web page at www.technologynetworks.com A 3D rendering of a lab-grown blood brain barrier carrying the APOE4 gene variant shows a heavy accumulation of amyloid on the vessel (green). Credit: Blanchard et. al./MIT Picower Institute By developing a lab-engineered model of the human blood-brain barrier (BBB), neuroscientists at MIT’s Picower Institute … Continue reading “Blood-Brain Barrier-in-a-Dish Leads to Alzheimer’s Discovery”
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Study finds path for addressing Alzheimer’s blood-brain barrier impairment
Click here to view original web page at www.sciencecodex.com IMAGE: A 3D rendering of a lab-grown blood brain barrier carrying the APOE4 gene variant shows a heavy accumulation of amyloid on the vessel (green). By developing a lab-engineered model of the human blood-brain barrier (BBB), neuroscientists at MIT’s Picower Institute for Learning and Memory have … Continue reading “Study finds path for addressing Alzheimer’s blood-brain barrier impairment”
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Study finds path for addressing Alzheimer’s blood-brain barrier impairment
Click here to view original web page at medicalxpress.com A 3D rendering of a lab-grown blood brain barrier carrying the APOE4 gene variant shows a heavy accumulation of amyloid on the vessel (green). Credit: Blanchard et. al./MIT Picower Institute By developing a lab-engineered model of the human blood-brain barrier (BBB), neuroscientists at MIT’s Picower Institute … Continue reading “Study finds path for addressing Alzheimer’s blood-brain barrier impairment”
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Denali unveils new way of crossing blood brain barrier as the big neuroscience bets enter its clinical years
Click here to view original web page at endpts.com Five years ago, as much of pharma began leaving neuroscience, three big-name scientists from Genentech and some A-list investors, including ARCH and Flagship, made a $217 million bet that new genetic insights and a reliance on biomarkers could bring them success. They called it Denali Therapeutics. … Continue reading “Denali unveils new way of crossing blood brain barrier as the big neuroscience bets enter its clinical years”
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Denali Therapeutics unveils blood-brain barrier delivery system
Click here to view original web page at cen.acs.org Case Hogan, who has Hunter syndrome, is in a clinical study of an intrathecally-delivered enzyme therapy. Researchers have long been vexed by the brain’s ability to shut out drugs. Now, Denali Therapeutics is offering evidence in mice and monkeys that a new drug delivery system can … Continue reading “Denali Therapeutics unveils blood-brain barrier delivery system”