Click here to view original web page at tRNA Fragments Linked to Alzheimer’s
Summary: A new study identifies a crucial factor in brain aging and Alzheimer’s disease—the accumulation of Glu-5’tsRNA-CTC in neuron mitochondria. This small RNA fragment disrupts mitochondrial protein synthesis and cristae structure, accelerating cognitive decline and Alzheimer’s pathology. By targeting these tRNA fragments with antisense oligonucleotides in aged mice, the […]