Figure 1. Schematic of the sole test of the thermal stimulation protocol used. Sensory discrimination dimension of thermal withdrawal response in normal aging male and female 3xTg-AD and age-matched NTg mice. (A) Infrared light stimulation was applied every 10 minutes under the sole surface of the hind paw (both […]
Tag: Alzheimer’s disease
A debilitating form of dementia, this progressive and irreversible neurode- generative disease results in the development of protein plaques and tangles that damages neurons and interfere with neural signaling, ultimately affecting memory and other important cognitive skills.
Three Advances in Alzheimer’s Disease Diagnostics
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Over the last year, Alzheimer’s disease research has been dominated by the somewhat unexpected, landmark approval of aducanumab – the first therapeutic for the condition in 20 years. But, when it comes to Alzheimer’s research in 2021, aducanumab is just one part of the story. Importantly, therapies based on […]
Product News: New biomarker test accurately predicts progression to Alzheimer’s disease six years before diagnosis
Diadem announces publication of clinical data showing its AlzoSure biomarker test is able to predict progression to Alzheimer’s disease years before symptoms are displayed. Diadem srl , a company developing the first blood-based test for the early prediction of progression to Alzheimer’s disease (AD), had announced results from a […]
Alzheimers Q&A: Are certain parts of the brain more vulnerable to Alzheimer’s disease?
Though researchers can’t pinpoint why individuals have different presentations of Alzheimer’s disease, one thing most people experience at the onset is short-term memory problems. It isn’t clear what causes certain regions of the brain to be affected first by the disease while many other parts seemingly are still functioning […]
Chronic Psychosocial Stress Could Lead to Alzheimer’s Disease
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Chronic stress, which involves a pathway called the hypothalamic-pituitary-adrenal (HPA) axis , may contribute to the development of Alzheimer’s disease, according to a new review paper. Armstrong et al. summarize the literature describing environmental and genetic factors that can impact an individual’s HPA axis reactivity and function and ultimately […]
New PET tracer detects hallmark of Alzheimer’s disease years before symptoms emerge
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1-year tau accumulation measured in composite A) mesial temporal ROI; B) Temporal parietal ROI of participants without cognitive impairment (blue) and participants with cognitive impairment (red). The CI group included participants with clinically mild cognitive impairment and dementia. Higher tau accumulation rates were observed in participants of the AD […]
Elemental Iron and Copper Found in the Brains of People With Alzheimer’s Disease
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X-ray spectromicroscopy on beamline I08 at the Diamond Light Source (UK). Credit: Neil Telling and James Everett A new study identifies the presence of the elemental metals iron and copper within plaques taken from the brains of people with Alzheimer’s disease (AD). As odd as it may sound, our […]
Cognetivity Neurosciences Files Patent For System Capable Of Early Detection Of Alzheimer’s Disease
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Cognetivity Neurosciences (CSE: CGN) this morning announced that it has filed for a key new patent. The filing relates to the use of an artificial intelligence-based system that estimates levels of core biomarkers of neurodegeneration within the brain, which can be utilized to detect, diagnose, and clinically manage disorders […]
Alzheimer’s Disease Pipeline Report: Current Therapies, Emerging Drugs, and Treatment Outlook
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Los Angeles, USA, May 31, 2021 (GLOBE NEWSWIRE) — Alzheimer’s Disease Pipeline Report: Current Therapies, Emerging Drugs, and Treatment Outlook Alzheimer’s Disease pipeline shows progress in the clinical trials with the upcoming therapies such as BAN2401, Gantenerumab, Bryostatin-1, INB03, AZT-211, and others. DelveInsight’s “ Alzheimer’s Disease Pipeline Insight ” […]
Age at Alzheimer’s disease onset may depend on history of psychiatric conditions
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Psychiatric conditions were associated with a younger age at onset of Alzheimer’s disease, and age differences only grew with each additional psychiatric diagnosis, researchers reported. “ Depression has been identified as a modifiable risk factor associated with Alzheimer’s disease (AD),” Zachary Miller, MD, an assistant professor and behavioral neurologist […]