Why the Memory of Fear Is Seared Into Our Brains

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Summary: Norepinephrine facilitates fear processing by stimulating a population of inhibitory neurons in the amygdala, generating repetitive bursting patterns of electrical activity. This activity changes the frequency of oscillations in the amygdala from resting state to aroused state, promoting the formation of fear memories. Source: Tulane University Experiencing a […]

When Eyes Meet, Neurons Start to Fire

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Summary: A specific set of socially tuned neurons fire across multiple regions across the prefrontal cortex and the amygdala at different times during mutual eye contact. The brain regions are recruited to compute selective aspects of interactive social gaze, suggesting the importance of a more contemplative role during social […]

When Severe Infection Causes Long-Term Mood Disorders

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Summary: The activation of a neural circuit comprising of the central nucleus of the amygdala and the bed nucleus of the stria terminalis in the first hours following sepsis infection induced anxiety behaviors in mice two weeks after the infection cleared. The behaviors mimicked the PTSD symptoms patients experience […]

The Neuroscience Behind Will Smith’s Attack on Chris Rock

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Key points The amygdala is a brain region that is activated when we perceive something to be threatening. The prefrontal cortex is the brain region responsible for suppressing the reflexive behavioral response triggered by amygdala activation. If the prefrontal cortex does its job, an individual should be able to […]

Amygdala Overgrowth in Babies Who Later Develop Autism

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Summary: Overgrowth of the amygdala at 6 – 12 months is an early indicator of autism diagnosis later in childhood and could be used as an early diagnostic for ASD in children. Source: UNC The amygdala is a small structure deep in the brain important for interpreting the social […]

Loneliness Has a Different Neural Basis Than Social Anxiety

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Summary: People with social anxiety have increased amygdala activity during social decision making, and reduced activity in the nucleus accumbens during social feedback. Those who are lonely did not experience the same alterations as those with social anxiety, suggesting loneliness is a unique condition. Source: SfN Despite similar symptoms, […]

Amygdala Changes in Autistic Individuals Linked to Anxiety

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Summary: Autistic children with traditional anxiety had significantly greater amygdala volume than children without ASD. Those with autism-distinct anxiety had significantly lower amygdala volume. Source: UC Davis A long-term study involving hundreds of brain scans finds changes in the amygdala linked to the development of anxiety in autistic children. […]

Locally produced neurosteroids regulate the emerging reproductive neural circuitry in the embryonic mouse brain

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This fluorescent image shows a sagittal section covering the embryonic mouse brain. Genetically labelled aromatase neurons (green) are restricted to amygdala areas close to the lateral ventricle. Nuclear staining is shown in blue. Credit: Wartenberg et al. The onset of puberty, the developmental stage at which adolescents reach sexual […]

Ketone 2-heptanone reduces inhibitory control of the amygdala in the mouse brain

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Single-unit extracellular recording. When the amygdala is electrically stimulated, neurons in the mPFC exhibit a brief period of activation, followed by a silent period and then an afterdischarge. Credit: Contreras & Gutiérrez-García. Alarm pheromones are substances that send danger signals to different parts of the brain. When these signals […]

The amygdala has been found to play an important role in the pre-attention mechanism of the brain

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Mouse brainstem inhibitory neurons (green) activated by amygdala input (magenta neuron process).Credit: University of Massachusetts Amherst We are all familiar with the startle reflex. The startle response is a sudden, uncontrollable jerk that occurs when you are surprised by noise or other unexpected stimuli. However, the brain also has […]